ICTV Virus Taxonomy Profile: Herpesviridae 2021

Author:

Gatherer Derek1,Depledge Daniel P.2,Hartley Carol A.3,Szpara Moriah L.4,Vaz Paola K.3,Benkő Mária5,Brandt Curtis R.6,Bryant Neil A.7,Dastjerdi Akbar8,Doszpoly Andor5,Gompels Ursula A.9,Inoue Naoki10,Jarosinski Keith W.11,Kaul Rajeev12,Lacoste Vincent13,Norberg Peter14,Origgi Francesco C.15,Orton Richard J.16,Pellett Philip E.17,Schmid D. Scott18,Spatz Stephen J.19,Stewart James P.20,Trimpert Jakob21,Waltzek Thomas B.22,Davison Andrew J.16

Affiliation:

1. Lancaster University, UK

2. NYU School of Medicine, New York, New York, USA

3. The University of Melbourne, Victoria, Australia

4. Pennsylvania State University, Pennsylvania, USA

5. Veterinary Medical Research Institute, Eötvös Loránd Research Network, Budapest, Hungary

6. University of Wisconsin-Madison, Madison, Wisconsin, USA

7. University of Cambridge, UK

8. Animal and Plant Health Agency-Weybridge, Addlestone, Surrey, UK

9. Virokine Therapeutics, London BioScience Innovation Centre, Royal Veterinary College, London, UK

10. Gifu Pharmaceutical University, Gifu, Japan

11. University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

12. University of Delhi South Campus, New Delhi, India

13. Institut Pasteur du Laos, Vientiane, Lao PDR, Laos

14. University of Gothenburg, Gothenburg, Sweden

15. University of Bern, Switzerland

16. University of Glasgow, UK

17. Wayne State University School of Medicine, Detroit, Michigan, USA

18. Centers for Disease Control and Prevention, Atlanta, Georgia, USA

19. US National Poultry Research Center, Athens, Georgia, USA

20. University of Liverpool, UK

21. Freie Universität Berlin, Berlin, Germany

22. University of Florida, Gainesville, Florida, USA

Abstract

Members of the family Herpesviridae have enveloped, spherical virions with characteristic complex structures consisting of symmetrical and non-symmetrical components. The linear, double-stranded DNA genomes of 125–241 kbp contain 70–170 genes, of which 43 have been inherited from an ancestral herpesvirus. In general, herpesviruses have coevolved with and are highly adapted to their hosts, which comprise many mammalian, avian and reptilian species. Following primary infection, they are able to establish lifelong latent infection, during which there is limited viral gene expression. Severe disease is usually observed only in the foetus, the very young, the immunocompromised or following infection of an alternative host. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Herpesviridae, which is available at ictv.global/report/herpesviridae.

Funder

Wellcome Trust

Publisher

Microbiology Society

Subject

Virology

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