NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal-Reference-Cited by-同舟云学术

NDM-8 Metallo-β-Lactamase in a Multidrug-Resistant Escherichia coli Strain Isolated in Nepal

Published:2013-05 Issue:5 Volume:57 Page:2394-2396
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tada Tatsuya¹,Miyoshi-Akiyama Tohru¹,Dahal Rajan K.²,Sah Manoj K.²,Ohara Hiroshi³,Kirikae Teruo¹,Pokhrel Bharat M.²

Affiliation:

1. Department of Infectious Diseases, Research Institute, Toyama, Shinjuku, Tokyo, Japan

2. National Center for Global Health and Medicine, Toyama, Shinjuku, Tokyo, Japan; Department of Microbiology, Institute of Medicine, Tribhuvan University, Maharajgunj, Kathmandu, Nepal

3. Department of International Medical Cooperation, Toyama, Shinjuku, Tokyo, Japan

Abstract

ABSTRACT A novel metallo-β-lactamase, NDM-8, was identified in a multidrug-resistant Escherichia coli isolate, IOMTU11 (NCGM37), obtained from the respiratory tract of a patient in Nepal. The amino acid sequence of NDM-8 has substitutions at positions 130 (Asp to Gly) and 154 (Met to Leu) compared with NDM-1. NDM-8 showed enzymatic activities against β-lactams similar to those of NDM-1.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.02553-12

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