Systemic Expression of a Viral RdRP Protects against Retrovirus Infection and Disease

Author:

Miller Caitlin M.1,Barrett Bradley S.1,Chen Jianfang1,Morrison James H.1,Radomile Caleb1,Santiago Mario L.1,Poeschla Eric M.1

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, School of Medicine, University of Colorado Anschutz Medical Center, Aurora, Colorado, USA

Abstract

Immune control of retroviruses is notoriously difficult, a fundamental problem that has been most clinically consequential with the HIV-1 pandemic. As humans expand further into previously uninhabited areas, the likelihood of new zoonotic retroviral exposures increases. The role of the innate immune system, including ISGs, in controlling retroviral infections is currently an area of intensive study. This work provides evidence that a primed innate immune system is an effective defense against retroviral pathogenesis, resulting in reduced viral replication and burden of disease outcomes. RdRP mice also had considerably lower Friend retrovirus (FV) viremia. The results could have implications for harnessing ISG responses to reduce transmission or control pathogenesis of human retroviral pathogens.

Funder

HHS | National Institutes of Health

John H. Tietze Foundation Trust

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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