Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing-Reference-Cited by-同舟云学术

Oritavancin Disrupts Membrane Integrity of Staphylococcus aureus and Vancomycin-Resistant Enterococci To Effect Rapid Bacterial Killing

Published:2010-12 Issue:12 Volume:54 Page:5369-5371
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Belley Adam¹,McKay Geoffrey A.¹,Arhin Francis F.¹,Sarmiento Ingrid¹,Beaulieu Sylvain¹,Fadhil Ibthihal¹,Parr Thomas R.¹,Moeck Gregory¹

Affiliation:

1. The Medicines Company, 7170 Frederick Banting, St. Laurent, Quebec, Canada H4S 2A1

Abstract

ABSTRACT Oritavancin is an investigational lipoglycopeptide in clinical development for the treatment of acute bacterial skin and skin structure infections. In this study, we demonstrate that oritavancin causes bacterial membrane depolarization and permeabilization leading to cell death of Gram-positive pathogens and that these effects are attributable to the 4′-chlorobiphenylmethyl group of the molecule.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00760-10

Reference18 articles.

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3. Arhin, F. F., I. Sarmiento, T. R. Parr, Jr., and G. Moeck. 2009. Comparative in vitro activity of oritavancin against Staphylococcus aureus strains that are resistant, intermediate or heteroresistant to vancomycin. J. Antimicrob. Chemother.64:868-870.

4. Oritavancin Kills Stationary-Phase and Biofilm Staphylococcus aureus Cells In Vitro

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