Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus <i>In Vitro</i>-Reference-Cited by-同舟云学术

Dioxane-Linked Novel Bacterial Topoisomerase Inhibitors Exhibit Bactericidal Activity against Planktonic and Biofilm Staphylococcus aureus In Vitro

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Chen Anna¹,Dellos-Nolan Sheri¹,Lu Yanran²,West Jason S.²,Wozniak Daniel J.¹³,Mitton-Fry Mark J.²^ORCID

Affiliation:

1. Microbial Infection and Immunity, College of Medicine, The Ohio State University, Columbus, Ohio, USA

2. Division of Medicinal Chemistry and Pharmacognosy, College of Pharmacy, The Ohio State University, Columbus, Ohio, USA

3. Department of Microbiology, College of Arts and Sciences, The Ohio State University, Columbus, Ohio, USA

Abstract

The pathogen Staphylococcus aureus contributes substantially to infection-related mortality. Biofilms render bacteria more recalcitrant to antibacterial therapy. The manuscript describes the potent activity of a new class of antibacterial agents against both planktonic and biofilm populations of Staphylococcus aureus .

Funder

HHS | National Institutes of Health

Dr. Ralph and Marian Falk Medical Research Trust

Chih-Ming and Jane Chen Graduate Fellowship Fund in Medicinal Chemistry and Pharmacognosy

Sick Kids Foundation

Start-up Funds

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02056-22