Metronidazole- and Carbapenem-Resistant Bacteroides thetaiotaomicron Isolated in Rochester, Minnesota, in 2014

Abstract

ABSTRACTEmerging antimicrobial resistance in members of theBacteroides fragilisgroup is a concern in clinical medicine. Although metronidazole and carbapenem resistance have been reported inBacteroides thetaiotaomicron, a member of theB. fragilisgroup, they have not, to the best of our knowledge, been reported together in the sameB. thetaiotaomicronisolate. Herein, we report isolation of piperacillin-tazobactam-, metronidazole-, clindamycin-, ertapenem-, and meropenem-resistantB. thetaiotaomicronfrom a patient with postoperative intra-abdominal abscess and empyema. Whole-genome sequencing demonstrated the presence ofnimDwith at least a portion of IS1169upstream, a second putativenimgene, two β-lactamase genes (one of which has not been previously reported), twotetXgenes,tetQ,ermF, twocatgenes, and a number of efflux pumps. This report highlights emerging antimicrobial resistance inB. thetaiotaomicronand the importance of identification and antimicrobial susceptibility testing of selected anaerobic bacteria.