Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells-Reference-Cited by-同舟云学术

Nonproductive Hepatitis B Virus Covalently Closed Circular DNA Generates HBx-Related Transcripts from the HBx/Enhancer I Region and Acquires Reactivation by Superinfection in Single Cells

Published:2023-01-31 Issue:1 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Peng Bo¹²,Jing Zhiyi²,Zhou Zhongmin²³,Sun Yinyan²,Guo Guilan²³,Tan Zexi²,Diao Yan²⁴,Yao Qiyan²⁵,Ping Yi²,Li Xuelei²⁶,Ren Tengfei²⁶,Li Bin²⁶,Li Wenhui²⁶^ORCID

Affiliation:

1. Graduate program in School of Life Sciences, Peking University, Beijing, China

2. National Institute of Biological Sciences, Beijing, China

3. Graduate program in School of Life Sciences, Beijing Normal University, Beijing, China

4. Graduate program in School of Life Sciences, Sun Yat-sen University, Guangzhou, China

5. Graduate program, Peking Union Medical College, Beijing, China

6. Tsinghua Institute of Multidisciplinary Biomedical Research, Tsinghua University, Beijing, China

Abstract

Hepatitis B virus (HBV) infection can be effectively suppressed but rarely cured by available drugs. Chronic HBV infection is based on persistence of covalently closed circular DNA (cccDNA) and continuous infection and reinfection with HBV in the liver.

Funder

National Natural Science Foundation of China

Ministry of Science and Technology of the People's Republic of China

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.01717-22

Reference43 articles.

1. A global scientific strategy to cure hepatitis B

2. Hepatitis B virus genome is organized into nucleosomes in the nucleus of the infected cell