Gepotidacin Pharmacokinetics-Pharmacodynamics against Escherichia coli in the One-Compartment and Hollow-Fiber In Vitro Infection Model Systems
Author:
Affiliation:
1. Institute for Clinical Pharmacodynamics, Schenectady, New York, USA
2. GlaxoSmithKline, Collegeville, Pennsylvania, USA
Abstract
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
Link
https://journals.asm.org/doi/pdf/10.1128/AAC.00122-21
Reference24 articles.
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3. Scangarella-Oman N Hossain M Tiemeyer TJ Jr Perry C Tiffany C Raychaudhuri A Dumont E. 2019. Microbiological analysis from a phase II study evaluating gepotidacin (GSK2140944) in the treatment of uncomplicated urinay tract infections. Abstr IDWeek 2019. Poster no. 1482.
4. Mushtaq S Vickers A Sadouki Z Cole M Fifer H Donascimento V Day M De Pinna E Jenkins C Godbole G Woodford N. 2019. In vitro activities of gepotidacin a novel triazaacenaphthylene topoisomerase IV and DNA gyrase inhibitor against Gram-negative bacteria and Staphylococcus saprophyticus. Abstr Eur Cong Clin Microbiol Infect Dis. Poster no. P1849.
5. Type IIA topoisomerase inhibition by a new class of antibacterial agents
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