Affiliation:
1. International Health Management Associates, Inc., Schaumburg, Illinois, USA
2. GlaxoSmithKline, Collegeville, Pennsylvania, USA
Abstract
ABSTRACT
Gepotidacin inhibits bacterial DNA replication through a mode different from that of fluoroquinolones. Gepotidacin and comparators were tested by broth and agar dilution against clinical isolates. The
in vitro
activities of gepotidacin were comparable against methicillin-susceptible and -resistant
Staphylococcus aureus
(MSSA and MRSA, respectively) isolates (MIC
90
, 0.5 μg/ml). The gepotidacin MIC
90
s were as follows (in micrograms per milliliter) for the indicated bacteria:
Streptococcus pyogenes
, 0.25;
Escherichia coli
, 2;
Moraxella catarrhalis
, ≤0.06;
Streptococcus pneumoniae
(0.25),
Haemophilus influenzae
, 1;
Clostridium perfringens
, 0.5; and
Shigella
spp., 1, including levofloxacin-resistant subsets. Gepotidacin warrants further investigation for clinical development.
Funder
DOD | Defense Threat Reduction Agency
Publisher
American Society for Microbiology
Subject
Infectious Diseases,Pharmacology (medical),Pharmacology
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