Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity-Reference-Cited by-同舟云学术

Anti-SARS-CoV-2 Antibody Levels Measured by the AdviseDx SARS-CoV-2 Assay Are Concordant with Previously Available Serologic Assays but Are Not Fully Predictive of Sterilizing Immunity

Published:2021-08-18 Issue:9 Volume:59 Page:
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Bradley Benjamin T.¹,Bryan Andrew¹,Fink Susan L.¹,Goecker Erin A.¹,Roychoudhury Pavitra¹^ORCID,Huang Meei-Li¹,Zhu Haiying¹,Chaudhary Anu¹,Madarampalli Bhanupriya¹,Lu Joyce Y. C.¹,Strand Kathy²,Whimbey Estella²,Bryson-Cahn Chloe²,Schippers Adrienne²,Mani Nandita S.²,Pepper Gregory¹,Jerome Keith R.¹³,Morishima Chihiro¹,Coombs Robert W.¹²,Wener Mark¹,Cohen Seth²,Greninger Alexander L.¹³^ORCID

Affiliation:

1. Department of Laboratory Medicine and Pathology, University of Washington Medical Center, Seattle, Washington, USA

2. Division of Infectious Diseases, Department of Medicine, University of Washington Medical Center, Seattle, Washington, USA

3. Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

Abstract

With the availability of widespread SARS-CoV-2 vaccination, high-throughput quantitative antispike serological testing will likely become increasingly important. Here, we investigated the performance characteristics of the recently FDA-authorized semiquantitative antispike AdviseDx SARS-CoV-2 IgG II assay compared to the FDA-authorized antinucleocapsid Abbott Architect SARS-CoV-2 IgG, Roche Elecsys anti-SARS-CoV-2-S, EuroImmun anti-SARS-CoV-2 enzyme-linked immunosorbent assay (ELISA), and GenScript surrogate virus neutralization assays and examined the humoral response associated with vaccination, natural protection, and breakthrough infection.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.00989-21

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