Virology—the path forward

Author:

Rasmussen Angela L.123ORCID,Gronvall Gigi K.4ORCID,Lowen Anice C.5ORCID,Goodrum Felicia6ORCID,Alwine James7,Andersen Kristian G.8,Anthony Simon J.9,Baines Joel10ORCID,Banerjee Arinjay1ORCID,Broadbent Andrew J.11ORCID,Brooke Christopher B.12ORCID,Campos Samuel K.6ORCID,Caposio Patrizia13ORCID,Casadevall Arturo14ORCID,Chan Gary C.15ORCID,Cliffe Anna R.16ORCID,Collins-McMillen Donna6,Connell Nancy17,Damania Blossom18ORCID,Daugherty Matthew D.19,Debbink Kari14,Dermody Terence S.20ORCID,DiMaio Daniel21ORCID,Duprex W. Paul2223ORCID,Emerman Michael24,Galloway Denise A.24,Garry Robert F.25,Goldstein Stephen A.26,Greninger Alexander L.27ORCID,Hartman Amy L.28ORCID,Hogue Brenda G.29,Horner Stacy M.30ORCID,Hotez Peter J.3132,Jung Jae U.33ORCID,Kamil Jeremy P.34ORCID,Karst Stephanie M.35,Laimins Lou36ORCID,Lakdawala Seema S.5ORCID,Landais Igor13,Letko Michael37ORCID,Lindenbach Brett38,Liu Shan-Lu3639ORCID,Luftig Micah40ORCID,McFadden Grant29ORCID,Mehle Andrew41ORCID,Morrison Juliet42,Moscona Anne434445ORCID,Mühlberger Elke46,Munger Joshua47ORCID,Münger Karl48,Murphy Eain15ORCID,Neufeldt Christopher J.5,Nikolich Janko Z.649,O'Connor Christine M.50ORCID,Pekosz Andrew14ORCID,Permar Sallie R.51ORCID,Pfeiffer Julie K.52ORCID,Popescu Saskia V.53,Purdy John G.6ORCID,Racaniello Vincent R.43,Rice Charles M.54,Runstadler Jonathan A.55ORCID,Sapp Martin J.34ORCID,Scott Rona S.34ORCID,Smith Gregory A.36ORCID,Sorrell Erin M.4,Speranza Emily56,Streblow Daniel13,Tibbetts Scott A.35ORCID,Toth Zsolt57ORCID,Van Doorslaer Koenraad6,Weiss Susan R.58ORCID,White Elizabeth A.59ORCID,White Timothy M.6,Wobus Christiane E.60ORCID,Worobey Michael61,Yamaoka Satoko62,Yurochko Andrew34ORCID

Affiliation:

1. Vaccine and Infectious Disease Organization, University of Saskatchewan, Saskatoon, Canada

2. Department of Biochemistry, Microbiology, and Immunology, University of Saskatchewan, Saskatoon, Canada

3. Department of Ecology and Evolution, Stony Brook University, Stony Brook, New York, USA

4. Department of Environmental Health and Engineering, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

5. Department of Microbiology and Immunology, Emory University, Atlanta, Georgia, USA

6. Department of Immunobiology, University of Arizona, Tucson, Arizona, USA

7. Department of Cancer Biology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

8. Department of Immunology and Microbiology, Scripps Research, La Jolla, California, USA

9. Department of Pathology, Microbiology, and Immunology, University of California, Davis, Davis, California, USA

10. Department of Microbiology and Immunology, Cornell University, Ithaca, New York, USA

11. Department of Animal and Avian Sciences, University of Maryland, College Park, Maryland, USA

12. Department of Microbiology, University of Illinois at Urbana-Champaign, Urbana, Illinois, USA

13. Vaccine and Gene Therapy Institute, Oregon Health and Science University, Beaverton, Oregon, USA

14. Department of Molecular Microbiology and Immunology, Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland, USA

15. Department of Microbiology and Immunology, SUNY Upstate Medical Center, Syracuse, New York, USA

16. Department of Microbiology, Immunology, and Cancer Biology, University of Virginia, Charlottesville, Virginia, USA

17. Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

18. Department of Microbiology and Immunology, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

19. Department of Molecular Biology, University of California, San Diego, La Jolla, California, USA

20. Department of Pediatrics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

21. Department of Genetics, Yale School of Medicine, New Haven, Connecticut, USA

22. Center for Vaccine Research, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

23. Department of Microbiology and Molecular Genetics, University of Pittsburgh, Pittsburgh, Pennsylvania, USA

24. Human Biology Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA

25. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, USA

26. Department of Human Genetics, University of Utah School of Medicine, Salt Lake City, Utah, USA

27. Department of Laboratory Medicine and Pathology, University of Washington, Seattle, Washington, USA

28. Department of Infectious Diseases and Microbiology, University of Pittsburgh School of Public Health, Pittsburgh, Pennsylvania, USA

29. School of Life Sciences, Arizona State University, Tempe, Arizona, USA

30. Department of Integrative Immunobiology, Duke University School of Medicine, Durham, North Carolina, USA

31. Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA

32. Department of Molecular Virology and Microbiology, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA

33. Department of Cancer Biology, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio, USA

34. Department of Microbiology and Immunology, Louisiana State University Health Sciences Center Shreveport, Shreveport, Louisiana, USA

35. Department of Molecular Genetics and Microbiology, University of Florida, Gainesville, Florida, USA

36. Department of Microbiology, Ohio State University, Wooster, Ohio, USA

37. Paul G. Allen School for Global Health, Washington State University, Pullman, Washington, USA

38. Department of Microbial Pathogenesis, Yale University, New Haven, USA

39. Viruses and Emerging Pathogens Program, Infectious Diseases Institute, Ohio State University, Wooster, Ohio, USA

40. Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, North Carolina, USA

41. Department of Medical Microbiology and Immunology, University of Wisconsin-Madison, Madison, Wisconsin, USA

42. Department of Microbiology and Plant Pathology, University of California, Riverside, Riverside, California, USA

43. Department of Microbiology and Immunology, Columbia University, New York, New York, USA

44. Department of Physiology, Columbia University, New York, New York, USA

45. Department of Biophysics, Columbia University, New York, New York, USA

46. Department of Virology, Immunology, and Microbiology, Boston University, Boston, Massachusetts, USA

47. Department of Biochemistry and Biophysics, University of Rochester, Rochester, New York, USA

48. Department of Developmental, Molecular, and Chemical Biology, Tufts University School of Medicine, Boston, Massachusetts, USA

49. Aegis Consortium for a Pandemic-Free Future, University of Arizona, Tucson, Arizona, USA

50. Department of Infection Biology, Cleveland Clinic, Cleveland, Ohio, USA

51. Department of Pediatrics, Weill Cornell Medicine, New York, New York, USA

52. Department of Microbiology, University of Texas Southwestern Medical Center, Dallas, Texas, USA

53. Department of Epidemiology and Public Health, University of Maryland School of Medicine, Baltimore, Maryland, USA

54. Laboratory of Virology and Infectious Disease, The Rockefeller University, New York, New York, USA

55. Department of Infectious Disease and Global Health, Cummings School of Veterinary Medicine at Tufts University, North Grafton, Massachusetts, USA

56. Florida Research and Innovation Center, Cleveland Clinic Lerner Research Institute, Port St. Lucie, Florida, USA

57. Department of Oral Biology, University of Florida, Gainesville, Florida, USA

58. Department of Microbiology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

59. Department of Otorhinolaryngology, University of Pennsylvania, Philadelphia, Pennsylvania, USA

60. Department of Microbiology and Immunology, University of Michigan, Ann Arbor, Michigan, USA

61. Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, Arizona, USA

62. Department of Infectious Diseases, Mayo Clinic, Rochester, Minnesota, USA

Abstract

ABSTRACT In the United States (US), biosafety and biosecurity oversight of research on viruses is being reappraised. Safety in virology research is paramount and oversight frameworks should be reviewed periodically. Changes should be made with care, however, to avoid impeding science that is essential for rapidly reducing and responding to pandemic threats as well as addressing more common challenges caused by infectious diseases. Decades of research uniquely positioned the US to be able to respond to the COVID-19 crisis with astounding speed, delivering life-saving vaccines within a year of identifying the virus. We should embolden and empower this strength, which is a vital part of protecting the health, economy, and security of US citizens. Herein, we offer our perspectives on priorities for revised rules governing virology research in the US.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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