Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data-Reference-Cited by-同舟云学术

Elucidation of Mechanisms of Ceftazidime Resistance among Clinical Isolates of Pseudomonas aeruginosa by Using Genomic Data

Published:2016-06 Issue:6 Volume:60 Page:3856-3861
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Kos Veronica N.¹,McLaughlin Robert E.¹,Gardner Humphrey A.²

Affiliation:

1. Infection Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA

2. Early Clinical Development Innovative Medicines Unit, AstraZeneca R&D Boston, Waltham, Massachusetts, USA

Abstract

ABSTRACT Ceftazidime is one of the few cephalosporins with activity against Pseudomonas aeruginosa . Using whole-genome comparative analysis, we set out to determine the prevalent mechanism(s) of resistance to ceftazidime (CAZ) using a set of 181 clinical isolates. These isolates represented various multilocus sequence types that consisted of both ceftazidime-susceptible and -resistant populations. A presumptive resistance mechanism against ceftazidime was identified in 88% of the nonsusceptible isolates using this approach.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.03113-15

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