The Pharmacodynamic-Toxicodynamic Relationship of AUC and C max in Vancomycin-Induced Kidney Injury in an Animal Model

Author:

Avedissian Sean N.12,Pais Gwendolyn34ORCID,Liu Jiajun34ORCID,O’Donnell J. Nicholas5ORCID,Lodise Thomas P.5ORCID,Neely Michael6,Prozialeck Walter C.7,Lamar Peter C.7,Becher Leighton3,Scheetz Marc H.347ORCID

Affiliation:

1. Antiviral Pharmacology Laboratory, University of Nebraska Medical Center Center for Drug Discovery, University of Nebraska Medical Center, Omaha, Nebraska, USA

2. University of Nebraska Medical Center, College of Pharmacy, Omaha, Nebraska, USA

3. Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

4. Midwestern University Chicago College of Pharmacy Center of Pharmacometric Excellence, Downers Grove, Illinois, USA

5. Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA

6. Children’s Hospital Los Angeles and University of Southern California, Los Angeles, California, USA

7. College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

Abstract

Vancomycin induces exposure-related acute kidney injury. However, the pharmacokinetic-toxicodynamic (PK-TD) relationship remains unclear.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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