Comparative Performance of Urinary Biomarkers for Vancomycin-Induced Kidney Injury According to Timeline of Injury

Author:

Pais Gwendolyn M.12,Avedissian Sean N.12,O’Donnell J. Nicholas3ORCID,Rhodes Nathaniel J.12ORCID,Lodise Thomas P.3,Prozialeck Walter C.4,Lamar Peter C.4,Cluff Cameron1,Gulati Anil5,Fitzgerald Julie C.6,Downes Kevin J.78,Zuppa Athena F.6,Scheetz Marc H.124ORCID

Affiliation:

1. Department of Pharmacy Practice, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

2. Pharmacometrics Center of Excellence, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

3. Department of Pharmacy Practice, Albany College of Pharmacy and Health Sciences, Albany, New York, USA

4. Department of Pharmacology, College of Graduate Studies, Midwestern University, Downers Grove, Illinois, USA

5. Department of Pharmaceutical Sciences, Chicago College of Pharmacy, Midwestern University, Downers Grove, Illinois, USA

6. Division of Critical Care, Department of Anesthesiology and Critical Care, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

7. Division of Infectious Diseases, The Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA

8. Department of Pediatrics, The University of Pennsylvania Perelman School of Medicine, Philadelphia, Pennsylvania, USA

Abstract

Urinary biomarkers are superior to serum creatinine for defining onset and extent of kidney injury. This study classifies the temporal predictive ability of biomarkers for vancomycin-induced kidney injury (VIKI) as defined by histopathologic damage.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

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