Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity-Reference-Cited by-同舟云学术

Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity

Published:2018-09 Issue:9 Volume:62 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Choi Seong Won¹,Gu Yuexi¹²,Peters Ryan Scott¹²,Salgame Padmini³,Ellner Jerrold J.⁴,Timmins Graham S.⁵,Deretic Vojo¹²

Affiliation:

1. Department of Molecular Genetics and Microbiology, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

2. Autophagy Inflammation and Metabolism Center of Biomedical Research Excellence, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

3. Division of Infectious Disease, Department of Medicine, Rutgers New Jersey Medical School, Newark, New Jersey, USA

4. Division of Infectious Disease, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA

5. Department of Pharmaceutical Sciences, University of New Mexico Health Sciences Center, Albuquerque, New Mexico, USA

Abstract

Host-directed therapy in tuberculosis is a potential adjunct to antibiotic chemotherapy directed at Mycobacterium tuberculosis . Ambroxol, a lead compound, emerged from a screen for autophagy-inducing drugs.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01019-18

Reference25 articles.

1. An Official ATS/IDSA Statement: Diagnosis, Treatment, and Prevention of Nontuberculous Mycobacterial Diseases

2. Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears