Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears-Reference-Cited by-同舟云学术

Early Bactericidal Activity of High-Dose Rifampin in Patients with Pulmonary Tuberculosis Evidenced by Positive Sputum Smears

Published:2007-08 Issue:8 Volume:51 Page:2994-2996
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Diacon A. H.¹,Patientia R. F.²,Venter A.³,van Helden P. D.³,Smith P. J.⁴,McIlleron H.⁴,Maritz J. S.⁵,Donald P. R.⁶

Affiliation:

1. Department of Internal Medicine

2. Tiervlei Trial Centre, Karl Bremer Hospital, Bellville, South Africa

3. Department of Molecular Biology and Human Genetics and MRC Centre for Molecular and Cellular Biology, DST/NRF Centre of Excellence for Biomedical TB Research

4. Division of Clinical Pharmacology, University of Cape Town, Cape Town, South Africa

5. Biostatistics Unit of the South African Medical Research Council, Cape Town, South Africa

6. Department of Paediatrics and Child Health, Faculty of Health Sciences, University of Stellenbosch, Tygerberg, South Africa

Abstract

ABSTRACT We studied the early bactericidal activity of twice the standard dose of rifampin in subjects with pulmonary tuberculosis evidenced by positive smears. The observed mean 2-day activity was almost double that reported at the standard dose. Further studies are warranted to establish whether higher rifampin doses might assist in shortening tuberculosis treatment.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01474-06

Reference21 articles.

1. Acocella, G. 1983. Pharmacokinetics and metabolism of rifampin in humans. Rev. Infect. Dis.5(Suppl. 3):S428-S432.

2. Bertrand, A. 1994. Antibiotic treatment of brucellosis. Presse Med.23:1128-1131.

3. Chan, S. L., W. W. Yew, W. K. Ma, D. J. Girling, V. R. Aber, D. Felmingham, B. W. Allen, and D. A. Mitchison. 1992. The early bactericidal activity of rifabutin measured by sputum viable counts in Hong Kong patients with pulmonary tuberculosis. Tuber. Lung Dis.73:33-38.

4. Grosset, J., and S. Leventis. 1983. Adverse effects of rifampin. Rev. Infect. Dis.5(Suppl. 3):S440-S450.

5. Jeanes, C. W., A. G. Jessamine, and L. Eidus. 1972. Treatment of chronic drug-resistant pulmonary tuberculosis with rifampin and ethambutol. Can. Med. Assoc. J.106:884-888.

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