Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus-Reference-Cited by-同舟云学术

Low Concentrations of Mupirocin in the Pharynx following Intranasal Application May Contribute to Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus

Published:2001-10 Issue:10 Volume:39 Page:3775-3777
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Watanabe Hiroshi¹,Masaki Hironori¹,Asoh Norichika¹,Watanabe Kiwao¹,Oishi Kazunori¹,Kobayashi Shinobu²,Sato Akiyoshi³,Sugita Rinya⁴,Nagatake Tsuyoshi¹

Affiliation:

1. Department of Internal Medicine, Institute of Tropical Medicine, Nagasaki University,1 and Departments of

2. Internal Medicine2 and

3. Microbiology,3 Kyorin Hospital, Nagasaki, and

4. Sugita Otorhinolaryngologic Clinic, Chiba,4 Japan

Abstract

ABSTRACT We describe a patient with methicillin-resistant Staphylococcus aureus (MRSA) colonizing the pharynx. The MIC of mupirocin was 0.25 μg/ml before treatment and increased after treatment to 8 μg/ml. Using pulsed-field gel electrophoresis, we confirmed that the genotypes of MRSA that colonized the pharynx before and after the use of mupirocin were identical. We measured the delivery of mupirocin to the pharynx in three normal volunteers and two patients. Low concentrations of mupirocin were present in the pharynx in all cases 10 min to 3 days after intranasal application. Our data suggested that low concentrations of the drug in the pharynx after intranasal application of mupirocin ointment might explain the selection of mupirocin resistance in MRSA.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.39.10.3775-3777.2001

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