Genetic Diversity among Mycobacterium bovis Isolates: a Preliminary Study of Strains from Animal and Human Sources-Reference-Cited by-同舟云学术

Genetic Diversity among Mycobacterium bovis Isolates: a Preliminary Study of Strains from Animal and Human Sources

Published:2001-12 Issue:12 Volume:39 Page:4558-4562
ISSN:0095-1137
Container-title:Journal of Clinical Microbiology
language:en
Short-container-title:J Clin Microbiol

Author:

Sales M. P. U.¹,Taylor G. M.²,Hughes S.³,Yates M.⁴,Hewinson G.³,Young D. B.²,Shaw R. J.¹

Affiliation:

1. Department of Respiratory Medicine, National Heart and Lung Institute,1 and

2. Department of Infectious Diseases and Microbiology,2

3. Imperial College, London SW7 2AZ, Veterinary Laboratory Agency, New Haw, Addlestone, Surrey KT15 3NB,3 and

4. Public Health Laboratory Service, Mycobacterium Reference Unit, King's College School of Medicine and Dentistry, King's College Hospital, East Dulwich Grove, London SE22 8QF,4 United Kingdom

Abstract

ABSTRACT Mycobacterium bovis has the broadest host range of species in the Mycobacterium tuberculosis complex and is responsible for disease in humans and diverse animal species. We report on genotypic differences at multiple loci among 13 isolates derived from a range of human and animal infections. All isolates were classified as M. bovis by phenotypic analysis but could be subdivided into five distinct genotypes based on polymorphisms at the pncA and oxyR loci, the status of the RD5 deletion region, and the spoligotype pattern. These findings suggest the existence of a spectrum of strains with genotypic characteristics between those of M. tuberculosis and M. bovis .

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

Link

https://journals.asm.org/doi/pdf/10.1128/JCM.39.12.4558-4562.2001

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