Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24 gag Epitope by HIV-1-Infected Children-Reference-Cited by-同舟云学术

Patient-Specific Cytotoxic T-Lymphocyte Cross-Recognition of Naturally Occurring Variants of a Human Immunodeficiency Virus Type 1 (HIV-1) p24 gag Epitope by HIV-1-Infected Children

Published:2001-05-15 Issue:10 Volume:75 Page:4941-4946
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Buseyne F.¹,Chaix M.-L.²,Rouzioux C.²,Blanche S.³,Rivière Y.¹

Affiliation:

1. Laboratoire d'Immunopathologie Virale, URA CNRS 1930, Institut Pasteur,1 and

2. Laboratoire de Virologie,2 and

3. Fédération de Pédiatrie,3 Hôpital Necker-Enfants Malades, 75015 Paris, France

Abstract

ABSTRACT We tested seven human immunodeficiency virus-infected children for their cytotoxic T-lymphocyte (CTL) activities towards the p24 gag QASQEVKNW epitope and its nine variant sequences. Our data confirm that most, but not all, CTL responses are broadly cross-specific. For the first time, we show the high interpatient variability in cross-recognition of mutant CTL epitopes. These interindividual variations in the CTL response to the same epitope should be taken into account in the design and the evaluation of vaccines.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.75.10.4941-4946.2001

Reference28 articles.

1. Cross-clade human immunodeficiency virus (HIV)-specific cytotoxic T-lymphocyte responses in HIV-infected Zambians

2. Individual variations in the murine T cell response to a specific peptide reflect variability in naive repertoires;Bousso P.;Immunity,1998

3. Evolution of a complex T cell receptor repertoire during primary and recall bacterial infection;Busch D. H.;J. Exp. Med.,1998

4. Detection of HIV-specific cell-mediated cytotoxicity in the peripheral blood from infected children;Buseyne F.;J. Immunol.,1993

5. Cross-clade-specific cytotoxic T lymphocytes in HIV-1 infected children;Buseyne F.;Virology,1998

Cited by 12 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Features of functional and dysfunctional CD8+ T cells to guide HIV vaccine development;Current Opinion in HIV and AIDS;2023-07-18

2. Molecular basis of differential HLA class I-restricted T cell recognition of a highly networked HIV peptide;Nature Communications;2023-05-22

3. Crystal structure of HLA-B*5801, a protective HLA allele for HIV-1 infection;Protein & Cell;2016-09-09

4. Fluctuations of functionally distinct CD8+ T-cell clonotypes demonstrate flexibility of the HIV-specific TCR repertoire;Blood;2006-03-15

5. A vaccinia-based elispot assay for detection of CD8+ T cells from HIV-1 infected children;Journal of Immunological Methods;2005-03