Role of Pseudomonas aeruginosa Glutathione Biosynthesis in Lung and Soft Tissue Infection

Author:

Michie Kelly L.123,Dees Justine L.4,Fleming Derek567ORCID,Moustafa Dina A.28,Goldberg Joanna B.28,Rumbaugh Kendra P.567,Whiteley Marvin123

Affiliation:

1. School of Biological Sciences, Georgia Institute of Technology, Atlanta, Georgia, USA

2. Emory-Children’s Cystic Fibrosis Center, Atlanta, Georgia, USA

3. Center for Microbial Dynamics and Infection, Georgia Institute of Technology, Atlanta, Georgia, USA

4. Department of Molecular Biosciences, University of Texas at Austin, Austin, Texas, USA

5. Department of Surgery, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

6. Department of Immunology and Molecular Microbiology, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

7. Burn Center of Research Excellence, Texas Tech University Health Sciences Center, Lubbock, Texas, USA

8. Department of Pediatrics, Emory University School of Medicine, Atlanta, Georgia, USA

Abstract

The opportunistic pathogen Pseudomonas aeruginosa is a leading cause of morbidity and mortality worldwide. To survive in both the environment and the host, P. aeruginosa must cope with redox stress. In P. aeruginosa , a primary mechanism for protection from redox stress is the antioxidant glutathione (GSH). GSH is a low-molecular-weight thiol-containing tripeptide ( l -γ-glutamyl- l -cysteinyl-glycine) that can function as a reversible reducing agent.

Funder

HHS | NIH | National Institute of General Medical Sciences

Cystic Fibrosis Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

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