Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4 + T Cells-Reference-Cited by-同舟云学术

Production of HIV-1 Env-Specific Antibodies Mediating Innate Immune Functions Depends on Cognate Interleukin-21- Secreting CD4 + T Cells

Published:2021-03-25 Issue:8 Volume:95 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pušnik Jernej¹²³,Fischinger Stephanie⁴,Dittmer Ulf⁵,Esser Stefan⁶,van Gils Marit J.⁷,Sanders Rogier W.⁷,Alter Galit⁴,Streeck Hendrik¹²³^ORCID

Affiliation:

1. Institute of Virology, University Hospital, University of Bonn, Bonn, Germany

2. German Center for Infection Research (DZIF), Partner Site Bonn-Cologne, Cologne, Germany

3. Institute for HIV Research, University Hospital, University Duisburg-Essen, Essen, Germany

4. Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Boston, Massachusetts, USA

5. Institute for Virology, University Hospital, University Duisburg-Essen, Essen, Germany

6. Center for HIV, AIDS and Venereal Diseases, Clinic for Dermatology, University Hospital, University Duisburg-Essen, Essen, Germany

7. Department of Medical Microbiology, Amsterdam UMC, Amsterdam Institute for Infection and Immunity, University of Amsterdam, Amsterdam, Netherlands

Abstract

To develop a vaccine or immunotherapy that would cure the HIV-1 infection, it is important to identify helper T cells able to mount an efficient antibody response. Here, we demonstrate that the generation of HIV-1 Env-specific antibodies facilitating antibody-dependent innate immune responses likely depends on Env-specific IL-21-secreting CD4 + T and peripheral T follicular helper cells.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.02097-20

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