Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response-Reference-Cited by-同舟云学术

Persistent Maintenance of Intermediate Memory B Cells Following SARS-CoV-2 Infection and Vaccination Recall Response

Published:2022-08-10 Issue:15 Volume:96 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Pušnik Jernej¹²,König Julia¹²,Mai Karola¹²,Richter Enrico¹²,Zorn Jasmin¹²,Proksch Hannah¹²,Schulte Bianca¹²,Alter Galit³,Streeck Hendrik¹²^ORCID

Affiliation:

1. Institute of Virology, University Hospital Bonn, Bonn, Germany

2. German Center for Infection Research (DZIF), partner site Bonn-Cologne, Braunschweig, Germany

3. Ragon Institute of MGH, MIT, and Harvard, Massachusetts General Hospital, Boston, Massachusetts, USA

Abstract

To efficiently maintain immunity against SARS-CoV-2 infection, we must first determine the durability of the immune response following infection or vaccination. Here, we demonstrated that, unlike antibodies, virus-specific memory B cells persist at high levels for at least 12 months postinfection and successfully respond to a secondary antigen challenge. Furthermore, we demonstrated that vaccination of previously infected individuals significantly boosters B cell immunity.

Funder

Government of North Rhine Westphalia

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00760-22

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