Defining the features and duration of antibody responses to SARS-CoV-2 infection associated with disease severity and outcome

Author:

Röltgen Katharina1ORCID,Powell Abigail E.2ORCID,Wirz Oliver F.1ORCID,Stevens Bryan A.1ORCID,Hogan Catherine A.1ORCID,Najeeb Javaria3,Hunter Molly4,Wang Hannah1ORCID,Sahoo Malaya K.1ORCID,Huang ChunHong1,Yamamoto Fumiko1,Manohar Monali56,Manalac Justin1,Otrelo-Cardoso Ana R.3ORCID,Pham Tho D.17,Rustagi Arjun8ORCID,Rogers Angela J.5ORCID,Shah Nigam H.9ORCID,Blish Catherine A.810ORCID,Cochran Jennifer R.11ORCID,Jardetzky Theodore S.3ORCID,Zehnder James L.1,Wang Taia T.81012ORCID,Narasimhan Balasubramanian1314ORCID,Gombar Saurabh1,Tibshirani Robert1314ORCID,Nadeau Kari C.56ORCID,Kim Peter S.210ORCID,Pinsky Benjamin A.18ORCID,Boyd Scott D.16ORCID

Affiliation:

1. Department of Pathology, Stanford University School of Medicine, Stanford, CA, USA.

2. Stanford ChEM-H and Department of Biochemistry, Stanford University School of Medicine, Stanford, CA, USA.

3. Department of Structural Biology, Stanford University, Stanford, USA.

4. ATUM, Newark, CA, USA

5. Department of Medicine, Division of Pulmonary, Allergy and Critical Care Medicine, Stanford University, Stanford, CA, USA.

6. Sean N. Parker Center for Allergy and Asthma Research, Stanford, CA, USA.

7. Stanford Blood Center, Palo Alto, CA, USA.

8. Department of Medicine, Division of Infectious Diseases and Geographic Medicine, Stanford University, Stanford, CA, USA.

9. Stanford Center for Biomedical Informatics Research, Stanford University, Stanford, California, USA

10. Chan Zuckerberg Biohub, San Francisco, CA, USA.

11. Department of Bioengineering, Stanford University, Stanford, CA, USA.

12. Department of Microbiology and Immunology, Stanford University, Stanford, CA, USA.

13. Department of Statistics, Stanford University, Stanford, CA, USA.

14. Department of Biomedical Data Sciences, Stanford University, Stanford, CA, USA.

Abstract

Illness severity in COVID-19 correlates with specificity of serological responses, but antibody levels decrease in most patients.

Funder

National Institutes of Health

National Institute of Allergy and Infectious Diseases

Stanford Maternal and Child Health Research Institute

Swiss National Science Foundation

NIH/NIAID

Crown Family Foundation

Publisher

American Association for the Advancement of Science (AAAS)

Subject

General Medicine,Immunology

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