MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata-Reference-Cited by-同舟云学术

MSH2 Gene Point Mutations Are Not Antifungal Resistance Markers in Candida glabrata

Published:2019-01 Issue:1 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bordallo-Cardona María Ángeles¹²,Agnelli Caroline¹²,Gómez-Nuñez Ana¹²,Sánchez-Carrillo Carlos¹²,Bouza Emilio¹²³⁴,Muñoz Patricia¹²³⁴,Escribano Pilar¹²,Guinea Jesús¹²³⁴^ORCID

Affiliation:

1. Clinical Microbiology and Infectious Diseases, Hospital General Universitario Gregorio Marañón, Madrid, Spain

2. Instituto de Investigación Sanitaria Gregorio Marañón, Madrid, Spain

3. CIBER Enfermedades Respiratorias (CIBERES) (CB06/06/0058), Madrid, Spain

4. Medicine Department, School of Medicine, Universidad Complutense de Madrid, Madrid, Spain

Abstract

The high rates of antifungal resistance in Candida glabrata may be facilitated by the presence of alterations in the MSH2 gene. We aimed to study the sequence of the MSH2 gene in 124 invasive C. glabrata isolates causing incident episodes of candidemia ( n = 81), subsequent candidemia episodes ( n = 9), endocarditis ( n = 2), and in vitro -generated echinocandin-resistant isolates ( n = 32) and assessed its relationship with genotypes, acquisition of antifungal resistance in vivo and in vitro , and patient prognosis.

Funder

Fondo de Investigación Sanitaria

FEDER

Instituto de Investigación Sanitaria Gregorio Marañón

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01876-18

Reference31 articles.

1. Molecular Identification and Antifungal Susceptibility of Yeast Isolates Causing Fungemia Collected in a Population-Based Study in Spain in 2010 and 2011