Demonstration of a High Level of Parasite Population Homology by Quantification of Plasmodium falciparum Alleles in Matched Peripheral, Placental, and Umbilical Cord Blood Samples

Author:

Jafari-Guemouri Sayeh1,Ndam Nicaise Tuikue1,Bertin Gwladys1,Renart Emily1,Sow Sokhna2,Le Hesran Jean-Yves3,Deloron Philippe1

Affiliation:

1. Faculté de Pharmacie, UR 010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), 75006 Paris, France

2. Hôpital de Thiadiaye, Sénégal

3. UR 010, Mother and Child Health in the Tropics, Institut de Recherche pour le Développement (IRD), BP1386, CP18524 Dakar, Sénégal

Abstract

ABSTRACT Plasmodium falciparum msp-1 and msp-2 genes were quantified by fragment analysis in matched placental, peripheral, and cord blood samples. In the three compartments, the multiplicity of infection values were similar, and parasite populations only partially overlapped, as reported. However, identical alleles represented 80 to 95% of the overall parasite populations of each compartment, demonstrating much more homogenous parasite populations than previously thought.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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