Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa-Reference-Cited by-同舟云学术

Acquisition of Class C β-Lactamase PAC-1 by Sequence Type 644 Strains of Pseudomonas aeruginosa

Published:2019-12 Issue:12 Volume:63 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bour Maxime¹,Fournier Damien¹,Jové Thomas²,Pouzol Armelle³,Miltgen Guillaume⁴,Janvier Frédéric⁵,Jeannot Katy¹⁶,Plésiat Patrick¹⁶^ORCID

Affiliation:

1. Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire de Besançon, Besançon, France

2. INSERM UMR 1092, Université de Limoges, Centre Hospitalier Universitaire de Limoges, Limoges, France

3. Laboratoire de Biologie Médicale, SELARL Manesq, Manosque, France

4. Laboratoire de Bactériologie, Centre Hospitalier Universitaire Félix Guyon, Saint Denis, France

5. Laboratoire de Microbiologie, Hôpital d’Instruction des Armées Sainte Anne, Toulon, France

6. CNRS UMR 6249 Chrono-Environnement, Université de Bourgogne Franche-Comté, Besançon, France

Abstract

Four sequence type 664 (ST664) (serotype O:5) strains of Pseudomonas aeruginosa that were highly resistant to antibiotics, including ceftolozane-tazobactam and ceftazidime-avibactam, but were susceptible to colistin were found to harbor the gene encoding the rare class C β-lactamase PAC-1 on a chromosomally located Tn 1721 -like transposon. The bla PAC-1 gene was associated with the 16S rRNA methylase determinant rmtF2 , which confers pan-aminoglycoside resistance.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.01375-19

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