Pharmacokinetics of Cefaclor in Normal Subjects and Patients with Chronic Renal Failure-Reference-Cited by-同舟云学术

Pharmacokinetics of Cefaclor in Normal Subjects and Patients with Chronic Renal Failure

Published:1977-12 Issue:6 Volume:12 Page:730-732
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Bloch Richard¹,Szwed James J.²,Sloan Rebecca S.¹,Luft Friedrich C.¹

Affiliation:

1. Renal Section, Department of Medicine, Indiana University Medical Center, Indianapolis, Indiana 46202

2. Wishard Hospital, Indianapolis, Indiana 46202

Abstract

We studied the pharmacokinetics of cefaclor, a new cephalosporin antibiotic, in normal subjects and subjects with chronic renal failure. Cefaclor was largely, but not entirely, eliminated by the kidneys. The cefaclor half-life in normal subjects was 40 to 60 min; in subjects with essentially no renal function, it increased to 3 h. In normal subjects, 50 to 70% of a 250-mg dose was excreted in the urine within 8 h. The linear relationship between the elimination constant and creatinine clearance allowed the construction of a useful dosage modification nomogram.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.12.6.730

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