Matrix Metalloproteinases Expressed in Response to Bacterial Vaginosis Disrupt the Endocervical Epithelium, Increasing Transmigration of HIV-Reference-Cited by-同舟云学术

Matrix Metalloproteinases Expressed in Response to Bacterial Vaginosis Disrupt the Endocervical Epithelium, Increasing Transmigration of HIV

Published:2020-03-23 Issue:4 Volume:88 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Cherne Michelle D.¹,Cole Amy L.¹,Newberry Lisa²,Schmidt-Owens Mary²,Deichen Michael²,Cole Alexander M.¹

Affiliation:

1. Laboratory of Innate Host Defense, Burnett School of Biomedical Sciences, College of Medicine, University of Central Florida, Orlando, Florida, USA

2. Student Health Services, University of Central Florida, Orlando, Florida, USA

Abstract

Bacterial vaginosis (BV), a disorder of the female reproductive tract (FRT) in which a healthy Lactobacillus -dominant microflora is replaced by BV-associated bacteria (BVAB), can significantly increase the incidence of human immunodeficiency virus (HIV) acquisition. Discerning the effect of BV on the mucosal epithelium of the FRT may yield novel preventatives and therapeutics for HIV infection. Here, we investigated barrier dysfunction of the endocervix by host-derived factors, secreted in response to BV, as a potential cause of HIV infection.

Funder

HHS | National Institutes of Health

UCF | College of Medicine, University of Central Florida

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/IAI.00041-20

Reference62 articles.

1. The global epidemiology of bacterial vaginosis: a systematic review

2. Nonspecific vaginitis