The A137R Protein of African Swine Fever Virus Inhibits Type I Interferon Production via the Autophagy-Mediated Lysosomal Degradation of TBK1

Author:

Sun Maowen12,Yu Shaoxiong1,Ge Hailiang12,Wang Tao1,Li Yongfeng1,Zhou Pingping1,Pan Li1,Han Yu1,Yang Yuying2,Sun Yuan1,Li Su1,Li Lian-Feng1,Qiu Hua-Ji12ORCID

Affiliation:

1. State Key Laboratory of Veterinary Biotechnology, National African Swine Fever Para-Reference Laboratory, National High Containment Facilities for Animal Diseases Control and Prevention, Harbin Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Harbin, China

2. College of Animal Sciences, Yangtze University, Jingzhou, China

Abstract

African swine fever (ASF) is a lethal viral disease of pigs caused by African swine fever virus (ASFV). No commercial vaccines and antiviral treatments are available for the prevention and control of the disease.

Funder

National Natural Science Foundation of China

Natural Science Foundation of Heilongjiang Province

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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