Killing Effect and Antitoxic Activity of the Leptospira interrogans Toxin-Antitoxin System in Escherichia coli-Reference-Cited by-同舟云学术

Killing Effect and Antitoxic Activity of the Leptospira interrogans Toxin-Antitoxin System in Escherichia coli

Published:2001-11 Issue:21 Volume:183 Page:6494-6497
ISSN:0021-9193
Container-title:Journal of Bacteriology
language:en
Short-container-title:J Bacteriol

Author:

Picardeau Mathieu¹,Ren Shuangxi²,Saint Girons Isabelle¹

Affiliation:

1. Unité de Bactériologie Moléculaire et Médicale, Institut Pasteur, Paris, France,1 and

2. Chinese Human Genome Center, Shanghai, China2

Abstract

ABSTRACT We report the first evidence of a chromosome-encoded toxin-antitoxin locus in spirochetes. This locus has been found in the pathogenic spirochete Leptospira interrogans and exhibits homologies with the pem / chp loci. The L. interrogans chp locus consists of two genes: chpK (for “killer protein”) and its upstream partner chpI (for “inhibitory protein”). Expression of ChpK in Escherichia coli results in the inhibition of bacterial growth. The coexpression of ChpI neutralizes ChpK toxicity. By Southern blot analysis, chp homologs were found in all representative pathogenic strains of L. interrogans .

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JB.183.21.6494-6497.2001

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