Complete Sequences of Multidrug Resistance Plasmids Bearing rmtD1 and rmtD2 16S rRNA Methyltransferase Genes

Abstract

ABSTRACT Complete nucleotide sequences were determined for two plasmids bearing rmtD group 16S rRNA methyltransferase genes. pKp64/11 was 78 kb in size, belonged to the IncL/M group, and harbored bla TEM-1b , sul1 , qacE Δ 1 , dfrA22 , and rmtD1 across two multidrug resistance regions (MRRs). pKp368/10 was 170 kb in size, belonged to the IncA/C group, and harbored acrB , sul1 , qacE Δ 1 , ant(3″)-Ia , aac(6′)-Ib , cat , rmtD2 , and bla CTX-M-8 across three MRRs. The rmtD -containing regions shared a conserved motif, suggesting a common origin for the two rmtD alleles.