Identification and Characterization of Novel Adeno-Associated Virus Isolates in ATCC Virus Stocks-Reference-Cited by-同舟云学术

Identification and Characterization of Novel Adeno-Associated Virus Isolates in ATCC Virus Stocks

Published:2006-05-15 Issue:10 Volume:80 Page:5082-5085
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Schmidt Michael¹,Grot Emmanuelle¹,Cervenka Peter¹,Wainer Sandra¹,Buck Charles²,Chiorini John A.¹

Affiliation:

1. Gene Therapy and Therapeutics Branch, National Institute of Dental and Craniofacial Research, National Institutes of Health, Bethesda, Maryland 20892

2. Department of Virology, American Type Culture Collection (ATCC), Manassas, Virginia 20108

Abstract

ABSTRACT Adeno-associated viruses (AAVs) depend on a helper virus for efficient replication. To identify novel AAV isolates, we screened a diverse set of virus isolates for the presence of AAV DNA. AAVs found in 10 simian adenovirus isolates showed greater than 96% homology to AAV1 and AAV6 but had distinct biological properties. Two representatives of this group, AAV(VR-195) and AAV(VR-355), were studied in more detail. While the novel AAVs had high sequence homologies and required sialic acid for cell binding and transduction, differences were observed in lectin competition, resulting in distinct tropisms in human cancer cell lines.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.80.10.5082-5085.2006

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