A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins-Reference-Cited by-同舟云学术

A Single Surface-Exposed Amino Acid Determines Differential Neutralization of AAV1 and AAV6 by Human Alpha-Defensins

Published:2023-03-30 Issue:3 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Porter Jessica M.¹,Oswald Mackenzi S.¹,Sharma Anjali¹,Emmanuel Shanan²,Kansol Austin²,Bennett Antonette²,McKenna Robert²^ORCID,Smith Jason G.¹^ORCID

Affiliation:

1. Department of Microbiology, University of Washington School of Medicine, Seattle, Washington, USA

2. Department of Biochemistry and Molecular Biology, University of Florida College of Medicine, Gainesville, Florida, USA

Abstract

The ability of adeno-associated viruses (AAVs) to infect and deliver genetic material to a range of cell types makes them favorable gene therapy vectors. However, AAV vectors encounter a wide variety of host immune factors throughout the body, which can impede efficient gene delivery.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | NIH Office of the Director

HHS | NIH | National Center for Advancing Translational Sciences

HHS | NIH | National Cancer Institute

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00060-23

Reference64 articles.