The High-Frequency Major Histocompatibility Complex Class I Allele Mamu-B * 17 Is Associated with Control of Simian Immunodeficiency Virus SIVmac239 Replication

Author:

Yant Levi J.12,Friedrich Thomas C.1,Johnson Randall C.3,May Gemma E.1,Maness Nicholas J.12,Enz Alissa M.1,Lifson Jeffrey D.4,O'Connor David H.12,Carrington Mary3,Watkins David I.12

Affiliation:

1. Wisconsin National Primate Research Center, University of Wisconsin—Madison, Madison, Wisconsin 53715

2. Department of Pathology and Laboratory Medicine, University of Wisconsin—Madison, Madison, Wisconsin 53715

3. Basic Research Program, Laboratory of Genomic Diversity, Science Applications International Corporation-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702

4. and AIDS Vaccine Program/Basic Research Program, Science Applications International Corporation-Fredrick, Frederick, Maryland 21072

Abstract

ABSTRACT Particular HLA alleles are associated with reduced human immunodeficiency virus replication. It has been difficult, however, to characterize the immune correlates of viral control. An analysis of the influence of major histocompatibility complex class I alleles on viral control in 181 simian immunodeficiency virus SIVmac239-infected rhesus macaques revealed that Mamu-B * 17 was associated with a 26-fold reduction in plasma virus concentrations ( P < 0.001). Mamu-B * 17 was also enriched 1,000-fold in a group of animals that controlled viral replication. Even after accounting for this group, Mamu-B * 17 was associated with an eightfold reduction in plasma virus concentrations ( P < 0.001). Mamu-B * 17- positive macaques could, therefore, facilitate our understanding of the correlates of viral control.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

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