The Influence of HLA Genotype on AIDS-Reference-Cited by-同舟云学术

The Influence of HLA Genotype on AIDS

Published:2003-02 Issue:1 Volume:54 Page:535-551
ISSN:0066-4219
Container-title:Annual Review of Medicine
language:en
Short-container-title:Annu. Rev. Med.

Author:

Carrington Mary¹²,O'Brien Stephen J.¹²

Affiliation:

1. Basic Research Program, SAIC-Frederick, Inc., National Cancer Institute, Frederick, Maryland 21702;

2. National Cancer Institute, Frederick, Maryland 21702;

Abstract

Genetic resistance to infectious diseases is likely to involve a complex array of immune-response and other genes with variants that impose subtle but significant consequences on gene expression or protein function. We have gained considerable insight into the genetic determinants of HIV-1 disease, and the HLA class I genes appear to be highly influential in this regard. Numerous reports have identified a role for HLA genotype in AIDS outcomes, implicating many HLA alleles in various aspects of HIV disease. Here we review the HLA associations with progression to AIDS that have been consistently affirmed and discuss the underlying mechanisms behind some of these associations based on functional studies of immune cell recognition.

Publisher

Annual Reviews

Subject

General Biochemistry, Genetics and Molecular Biology,General Medicine

Link

https://www.annualreviews.org/doi/pdf/10.1146/annurev.med.54.101601.152346

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