Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves-Reference-Cited by-同舟云学术

Quantitative Pharmacodynamic Characterization of Resistance versus Heteroresistance of Colistin in E. coli Using a Semimechanistic Modeling of Killing Curves

Published:2022-09-20 Issue:9 Volume:66 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Mead Andrew¹^ORCID,Toutain Pierre-Louis¹²^ORCID,Richez Pascal³,Pelligand Ludovic¹⁴^ORCID

Affiliation:

1. Comparative Biomedical Sciences, The Royal Veterinary College, London, United Kingdom

2. INTHERES, Université de Toulouse, INRAE, ENVT, Toulouse, France

3. TransPharm, Saint-Genies des Mourgues, France

4. Clinical Services and Sciences, The Royal Veterinary College, London, United Kingdom

Abstract

Heteroresistance corresponds to the presence, in a bacterial isolate, of an initial small subpopulation of bacteria characterized by a significant reduction in their sensitivity to a given antibiotic. Mechanisms of heteroresistance versus resistance are poorly understood.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

Dopharma

VMD/Inovet

Virbac

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/aac.00793-22

Reference46 articles.