Identification of a TAP-Independent, Immunoproteasome-Dependent CD8 + T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2-Reference-Cited by-同舟云学术

Identification of a TAP-Independent, Immunoproteasome-Dependent CD8 + T-Cell Epitope in Epstein-Barr Virus Latent Membrane Protein 2

Published:2003-02-15 Issue:4 Volume:77 Page:2757-2761
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Lautscham Georg¹,Haigh Tracey¹,Mayrhofer Sabine¹,Taylor Graham¹,Croom-Carter Debbie¹,Leese Alison¹,Gadola Stephan²,Cerundolo Vincenzo²,Rickinson Alan¹,Blake Neil¹³

Affiliation:

1. Cancer Research UK Institute for Cancer Studies, University of Birmingham, Birmingham

2. Institute of Molecular Medicine, John Radcliffe Hospital, Oxford

3. Department of Medical Microbiology, University of Liverpool, Liverpool, United Kingdom

Abstract

ABSTRACT We have identified an HLA-A2-restricted CD8 + T-cell epitope, FLYALALLL, in the Epstein-Barr virus (EBV) latent membrane protein 2 (LMP2), an important target antigen in the context of EBV-associated malignancies. This epitope is TAP independent, like other hydrophobic LMP2-derived epitopes, but uniquely is dependent upon the immunoproteasome for its generation.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/JVI.77.4.2757-2761.2003

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