Pseudomonas aeruginosa Clinical Isolates in Nepal Coproducing Metallo-β-Lactamases and 16S rRNA Methyltransferases-Reference-Cited by-同舟云学术

Pseudomonas aeruginosa Clinical Isolates in Nepal Coproducing Metallo-β-Lactamases and 16S rRNA Methyltransferases

Published:2017-09 Issue:9 Volume:61 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Tada Tatsuya¹²,Shimada Kayo¹,Satou Kazuhito³^ORCID,Hirano Takashi³⁴,Pokhrel Bharat M.⁵,Sherchand Jeevan B.⁵,Kirikae Teruo¹²

Affiliation:

1. Department of Infectious Diseases, Research Institute, National Center for Global Health and Medicine, Tokyo, Japan

2. Department of Microbiology, Juntendo University School of Medicine, Tokyo, Japan

3. Okinawa Institute of Advanced Sciences, Okinawa, Japan

4. SENTAN Pharma, Inc., Fukuoka, Japan

5. Tribhuvan University, Institute of Medicine, Department of Microbiology, Maharajgunj, Kathmandu, Nepal

Abstract

ABSTRACT A total of 11 multidrug-resistant Pseudomonas aeruginosa clinical isolates were obtained in Nepal. Four of these isolates harbored genes encoding one or more carbapenemases (DIM-1, NDM-1, and/or VIM-2), and five harbored genes encoding a 16S rRNA methyltransferase (RmtB4 or RmtF2). A novel RmtF variant, RmtF2, had a substitution (K65E) compared with the same gene in RmtF. To our knowledge, this is the first report describing carbapenemase- and 16S rRNA methyltransferase-coproducing P. aeruginosa clinical isolates in Nepal.

Funder

International Health Cooperation Research

Okinawa Communicable Disease Research Hub Formation Promotion Project

Research Program on Emerging and Re-emerging Infectious Diseases from AMED

JSPS KAKENHI

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00694-17

Reference20 articles.