Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc-Reference-Cited by-同舟云学术

Novel Transmission-Blocking Antimalarials Identified by High-Throughput Screening of Plasmodium berghei Ookluc

Published:2023-04-18 Issue:4 Volume:67 Page:
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Calit Juliana¹,Araújo Jessica E.²³,Deng Bingbing⁴,Miura Kazutoyo⁴,Gaitán Xiomara A.¹,Araújo Maisa da Silva²,Medeiros Jansen F.²³,Long Carole A.⁴,Simeonov Anton⁵^ORCID,Eastman Richard T.⁵^ORCID,Bargieri Daniel Y.¹^ORCID

Affiliation:

1. Department of Parasitology, Institute of Biomedical Sciences, University of São Paulo, São Paulo, São Paulo, Brazil

2. Plataforma de Produção e Infecção de Vetores da Malária-PIVEM, Laboratório de Entomologia, Fundação Oswaldo Cruz-Fiocruz Rondônia, Porto Velho, Rondônia, Brazil

3. Programa de Pós-graduação em Biologia Experimental, Universidade Federal de Rondônia/Fiocruz Rondônia, Porto Velho, Rondônia, Brazil

4. Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Rockville, Maryland, USA

5. Division of Preclinical Innovation, National Center for Advancing Translational Sciences, National Institutes of Health, Rockville, Maryland, USA

Abstract

Safe and effective malaria transmission-blocking chemotherapeutics would allow a community-level approach to malaria control and eradication efforts by targeting the mosquito sexual stage of the parasite life cycle. However, only a single drug, primaquine, is currently approved for use in reducing transmission, and drug toxicity limits its widespread implementation.

Funder

Division of Intramural Research, National Institute of Allergy and Infectious Diseases

Fundação de Amparo à Pesquisa do Estado de São Paulo

HHS | NIH | National Center for Advancing Translational Sciences

Instituto Serrapilheira

International Centers of Excellence for Malaria Research

Bill and Melinda Gates Foundation

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology