Farnesol Concentrations Required To Block Germ Tube Formation in Candida albicans in the Presence and Absence of Serum

Author:

Mosel Daniel D.1,Dumitru Raluca1,Hornby Jacob M.1,Atkin Audrey L.1,Nickerson Kenneth W.1

Affiliation:

1. School of Biological Sciences, University of Nebraska, Lincoln, Nebraska 68588-0666

Abstract

ABSTRACT Concentrations of ( E , E )-farnesol needed to inhibit germ tube formation were determined for Candida albicans strains A72 and SC5314 by using six different conditions known to trigger germination. For defined media, 1 to 2 μM farnesol was sufficient. However, with serum at 2 to 20%, up to 250 μM farnesol was required. Farnesol blocked germ tube formation but did not block elongation of existing germ tubes.

Publisher

American Society for Microbiology

Subject

Ecology,Applied Microbiology and Biotechnology,Food Science,Biotechnology

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