A Decline in Mupirocin Resistance in Methicillin-Resistant Staphylococcus aureus Accompanied Administrative Control of Prescriptions

Author:

Walker Elaine S.12,Levy Foster3,Shorman Mahmoud12,David Gerard12,Abdalla Jehad12,Sarubbi Felix A.12

Affiliation:

1. James H. Quillen Veterans Affairs Medical Center, Mountain Home, Tennessee 37684

2. Department of Internal MedicineJames H. Quillen College of Medicine

3. Department of Biological Sciences, East Tennessee State University, Johnson City, Tennessee 37614

Abstract

ABSTRACT Susceptibility to mupirocin was assessed in methicillin-resistant Staphylococcus aureus isolates selected from eras corresponding to differences in usage rate and prescription policies at a Veterans Affairs medical center. The eras studied encompassed from the time of introduction of the drug to its widespread use, through recommended judicious use, and finally to subsequent stringent administrative control. Prescriptions declined from 3.0 to 0.1 per 1,000 patient days. Precipitous declines first in the numbers of isolates with high-level resistance (from 31% to 4%) and then in those with low-level resistance (from 26% to 10%) accompanied prescription control.

Publisher

American Society for Microbiology

Subject

Microbiology (medical)

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