Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis-Reference-Cited by-同舟云学术

Standardization of an Experimental Murine Model of Invasive Pulmonary Aspergillosis

Published:2006-10 Issue:10 Volume:50 Page:3501-3503
ISSN:0066-4804
Container-title:Antimicrobial Agents and Chemotherapy
language:en
Short-container-title:Antimicrob Agents Chemother

Author:

Sheppard Donald C.¹,Graybill John R.²,Najvar Laura K.²,Chiang Lisa Y.³,Doedt Thomas³,Kirkpatrick William R.²,Bocanegra Rosie²,Vallor Ana C.²,Patterson Thomas F.²,Filler Scott G.³⁴

Affiliation:

1. Department of Microbiology and Immunology, McGill University, Montreal, Canada

2. The University of Texas Health Science Center at San Antonio, Department of Medicine, Division of Infectious Diseases San Antonio, Texas

3. Division of Infectious Diseases, Department of Medicine, Los Angeles Biomedical Research Institute at Harbor-UCLA Medical Center, Torrance, California

4. The David Geffen School of Medicine at UCLA, Los Angeles, California

Abstract

ABSTRACT Evaluating new therapeutic agents for invasive aspergillosis requires animal models that are reproducible among different laboratories. We therefore evaluated a murine model of aerosol infection in two independent laboratories and found a high level of both intra- and interlaboratory reproducibility of survival, fungal burden over time, and the efficacy of liposomal amphotericin B.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Pharmacology (medical),Pharmacology

Link

https://journals.asm.org/doi/pdf/10.1128/AAC.00787-06

Reference13 articles.

1. Bellocchio, S., R. Gaziano, S. Bozza, G. Rossi, C. Montagnoli, K. Perruccio, M. Calvitti, L. Pitzurra, and L. Romani. 2005. Liposomal amphotericin B activates antifungal resistance with reduced toxicity by diverting Toll-like receptor signaling from TLR-2 to TLR-4. J. Antimicrob. Chemother.55:214-222.

2. Quantitative PCR Assay To Measure Aspergillus fumigatus Burden in a Murine Model of Disseminated Aspergillosis: Demonstration of Efficacy of Caspofungin Acetate

3. Experimental Study of the Pathogenicity of Aspergilli for Mice

4. Anti- Aspergillus fumigatus Efficacy of Pentraxin 3 Alone and in Combination with Antifungals

5. Graybill, J. R., S. R. Kaster, and D. J. Drutz. 1983. Treatment of experimental murine aspergillosis with BAY n7133. J. Infect. Dis.148:898-906.

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