AcrB Multidrug Efflux Pump of Escherichia coli : Composite Substrate-Binding Cavity of Exceptional Flexibility Generates Its Extremely Wide Substrate Specificity
Author:
Affiliation:
1. Department of Molecular and Cell Biology, University of California, Berkeley, California 94720-3202
Publisher
American Society for Microbiology
Subject
Molecular Biology,Microbiology
Link
https://journals.asm.org/doi/pdf/10.1128/JB.185.19.5657-5664.2003
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3. Carredano, E., A. Karisson, B. Kauppi, D. Choudhury, R. E. Parales, J. V. Parales, K. Lee, D. T. Gibson, H. Eklund, and S. Ramaswamy. 2000. Substrate binding site of naphthalene 1, 2-dioxygenase: functional implications of indole binding. J. Mol. Biol.321:621-632.
4. Chang, G., and C. B. Roth. 2001. Structure of MsbA from E. coli: a homolog of the multidrug resistance ATP binding cassette (ABC) transporters. Science293:1793-1800.
5. Davies, J. P., F. W. Chen, and Y. A. Ioannou. 2000. Transmembrane molecular pump activity of Niemann-Pick C1 protein. Science290:2295-2298.
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