Development of pharmacophore models for AcrB protein and the identification of potential adjuvant candidates for overcoming efflux-mediated colistin resistance-Reference-Cited by-同舟云学术

Development of pharmacophore models for AcrB protein and the identification of potential adjuvant candidates for overcoming efflux-mediated colistin resistance

Published:2024 Issue:1 Volume:15 Page:127-138
ISSN:2632-8682
Container-title:RSC Medicinal Chemistry
language:en
Short-container-title:RSC Med. Chem.

Author:

Behera Dibyajyoti Uttameswar¹^ORCID,Gaur Mahendra²³^ORCID,Sahoo Maheswata¹^ORCID,Subudhi Enketeswara¹^ORCID,Subudhi Bharat Bhusan²^ORCID

Affiliation:

1. Centre for Biotechnology, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India

2. Drug Development and Analysis Laboratory, School of Pharmaceutical Sciences, Siksha ‘O’ Anusandhan (Deemed to be University), Kalinga Nagar, Ghatikia, Bhubaneswar-751003, Odisha, India

3. Department of Biotechnology & Food Technology, Punjabi University, Patiala 147002, India

Abstract

Screening of FDA approved drugs against ligand-based pharmacophore model identified argatroban as efflux pump inhibitor that enhanced the susceptibility to colistin.

Funder

Indian Council of Medical Research

Department of Biotechnology, Ministry of Science and Technology, India

Publisher

Royal Society of Chemistry (RSC)

Subject

Organic Chemistry,Drug Discovery,Pharmaceutical Science,Pharmacology,Molecular Medicine,Biochemistry

Link

http://pubs.rsc.org/en/content/articlepdf/2024/MD/D3MD00483J

Reference80 articles.

1. Colistin and its role in the Era of antibiotic resistance: an extended review (2000–2019)

2. Mutations in two component system (PhoPQ and PmrAB) in colistin resistant Klebsiella pneumoniae from North Indian tertiary care hospital

3. Efflux pump inhibitor CCCP to rescue colistin susceptibility in mcr-1 plasmid-mediated colistin-resistant strains and Gram-negative bacteria

4. Polymyxins, the last-resort antibiotics: Mode of action, resistance emergence, and potential solutions

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