<i>para</i> -Aminobenzoic Acid Biosynthesis Is Required for Listeria monocytogenes Growth and Pathogenesis-Reference-Cited by-同舟云学术

para -Aminobenzoic Acid Biosynthesis Is Required for Listeria monocytogenes Growth and Pathogenesis

Published:2022-11-17 Issue:11 Volume:90 Page:
ISSN:0019-9567
Container-title:Infection and Immunity
language:en
Short-container-title:Infect Immun

Author:

Zhang Yingying¹²,Anaya-Sanchez Andrea³,Portnoy Daniel A.¹⁴^ORCID

Affiliation:

1. Department of Molecular and Cell Biology, University of California, Berkeley, Berkeley, California, USA

2. California Institute for Quantitative Biosciences-Berkeley (QB3-Berkeley), University of California, Berkeley, Berkeley, California, USA

3. Graduate Group in Microbiology, University of California, Berkeley, Berkeley, California, USA

4. Department of Plant and Microbial Biology, University of California, Berkeley, Berkeley, California, USA

Abstract

Biosyntheses of para -aminobenzoic acid (PABA) and its downstream folic acid metabolites are essential for one-carbon metabolism in all life forms and the targets of sulfonamide and trimethoprim antibiotics. In this study, we identified and characterized two genes ( pabA and pabBC ) required for PABA biosynthesis in Listeria monocytogenes .

Funder

HHS | National Institutes of Health

The UC Berkeley Tang Distinguished Scholarship

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Immunology,Microbiology,Parasitology

Link

https://journals.asm.org/doi/pdf/10.1128/iai.00207-22

Reference69 articles.

1. Listeria monocytogenes — from saprophyte to intracellular pathogen

2. Listeria monocytogenes: towards a complete picture of its physiology and pathogenesis