Draft Genome Sequence of Actinoplanes utahensis NRRL 12052, a Microorganism Involved in Industrial Production of Pharmaceutical Intermediates-Reference-Cited by-同舟云学术

Draft Genome Sequence of Actinoplanes utahensis NRRL 12052, a Microorganism Involved in Industrial Production of Pharmaceutical Intermediates

Published:2015-02-26 Issue:1 Volume:3 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Velasco-Bucheli Rodrigo¹,del Cerro Carlos²,Hormigo Daniel¹,Acebal Carmen¹,Arroyo Miguel¹,García José L.²,de la Mata Isabel¹

Affiliation:

1. Department of Biochemistry and Molecular Biology I, Facultad de Biología, Universidad Complutense de Madrid, Madrid, Spain

2. Department of Environmental Biology, Centro de Investigaciones Biológicas, Consejo Superior de Investigaciones Científicas, Madrid, Spain

Abstract

ABSTRACT Here, we describe the draft genome sequence of Actinoplanes utahensis NRRL 12052, a filamentous bacterium that encodes an aculeacin A acylase and a putative N -acyl-homoserine lactone acylase of biotechnological interest. Moreover, several nonribosomal peptide synthase (NRPS) and polyketide synthase (PKS) clusters and antibiotic resistance genes have been identified.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.01411-14

Reference18 articles.

1. Newly Discovered Penicillin Acylase Activity of Aculeacin A Acylase from Actinoplanes utahensis

2. Deacylation of echinocandin B by Actinoplanes utahensis.

3. Synthesis of new analogs of echinocandin B by enzymatic deacylation and chemical reacylation of the echinocandin B peptide: Synthesis of the antifungal agent cilofungin (LY121019).

4. Deacylation of A21978C, an acidic lipopeptide antibiotic complex, by Actinoplanes utahensis.

5. Membrane-associated echinocandin B deacylase of Actinoplanes utahensis : purification, characterization, heterologous cloning and enzymatic deacylation reaction

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