Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology-Reference-Cited by-同舟云学术

Complete Genome Sequences of Eight Helicobacter pylori Strains with Different Virulence Factor Genotypes and Methylation Profiles, Isolated from Patients with Diverse Gastrointestinal Diseases on Okinawa Island, Japan, Determined Using PacBio Single-Molecule Real-Time Technology

Published:2014-05 Issue:2 Volume:2 Page:
ISSN:2169-8287
Container-title:Genome Announcements
language:en
Short-container-title:Genome Announc

Author:

Satou Kazuhito¹,Shiroma Akino¹,Teruya Kuniko¹,Shimoji Makiko¹,Nakano Kazuma¹,Juan Ayaka¹,Tamotsu Hinako¹,Terabayashi Yasunobu¹,Aoyama Misako¹,Teruya Morimi²,Suzuki Rumiko³,Matsuda Miyuki³,Sekine Akihiro⁴,Kinjo Nagisa⁵,Kinjo Fukunori⁵,Yamaoka Yoshio³⁶,Hirano Takashi¹

Affiliation:

1. Okinawa Institute of Advanced Sciences, Uruma, Japan

2. Okinawa Industrial Technology Center, Uruma, Japan

3. Department of Environmental and Preventive Medicine, Oita University Faculty of Medicine, Yufu, Japan

4. Pharmacogenomics Project, Kyoto University Graduate School of Medicine, Kyoto, Japan

5. Department of Endoscopy, University Hospital, University of the Ryukyus, Nishihara, Japan

6. Department of Medicine–Gastroenterology, Baylor College of Medicine and Michael E. DeBakey Veterans Affairs Medical Center, Houston, Texas, USA

Abstract

ABSTRACT We report the complete genome sequences of eight Helicobacter pylori strains isolated from patients with gastrointestinal diseases in Okinawa, Japan. Whole-genome sequencing and DNA methylation detection were performed using the PacBio platform. De novo assembly determined a single, complete contig for each strain. Furthermore, methylation analysis identified virulence factor genotype-dependent motifs.

Publisher

American Society for Microbiology

Subject

Genetics,Molecular Biology

Link

https://journals.asm.org/doi/pdf/10.1128/genomeA.00286-14

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