Cryptococcus neoformans III. Inhibition of Phagocytosis

Author:

Bulmer G. S.1,Sans M. D.1

Affiliation:

1. Department of Microbiology, University of Oklahoma School of Medicine, Oklahoma City, Oklahoma 73104

Abstract

Isolated nonhydrolyzed cryptococcal polysaccharide is a rather specific potent inhibitor of the phagocytosis of Cryptococcus neoformans by human leukocytes in vitro. When an encapsulated strain of C. neoformans was cultured in the nonencapsulated state, the rate of phagocytosis was three times greater than when the encapsulated form was used. Our theory that capsular material plays a role in the pathogenesis of cryptococcosis requires (i) that C. neoformans exist in soil in a nonencapsulated state and (ii) that human phagocytes be capable of killing the organisms.

Publisher

American Society for Microbiology

Subject

Molecular Biology,Microbiology

Reference6 articles.

1. Further studies on acquired resistance to murine cryptococcosis: Enhancing effect of Bordetella pertussis;ABRAHAMS I.;J. Immunol.,1966

2. Investigations on the structure of the capsular polysaccharide from Cryptococcus neoformans, type B;BLANDAMER A.;Biochim. Biophys. Acta,1966

3. Cryptococcus neoformans. I. Nonencapsulated mutants;BULMER G. S.;J. Bacteriol.,1967

4. Cryptococcus neoformans. II. Phagocytosis by human leukocytes;BULMER G. S.;J. Bacteriol.,1967

5. Effect of degree of encapsulation upon virulence of Cryptococcus neoformans;AN M. L.;Proc. Soc. Exptl. Biol. Med.,1959

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