The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans-Reference-Cited by-同舟云学术

The Transcription Factor Pdr802 Regulates Titan Cell Formation and Pathogenicity of Cryptococcus neoformans

Published:2021-04-27 Issue:2 Volume:12 Page:
ISSN:2150-7511
Container-title:mBio
language:en
Short-container-title:mBio

Author:

Reuwsaat Julia C. V.¹²,Agustinho Daniel P.²,Motta Heryk¹,Chang Andrew L.²,Brown Holly²,Brent Michael R.³⁴⁵,Kmetzsch Livia¹⁶^ORCID,Doering Tamara L.²^ORCID

Affiliation:

1. Molecular Biology of Pathogens Laboratory, Biotechnology Center, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

2. Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, Missouri, USA

3. Center for Genome Sciences and Systems Biology, Washington University School of Medicine, St. Louis, Missouri, USA

4. Department of Computer Science and Engineering, Washington University, St. Louis, Missouri, USA

5. Department of Genetics, Washington University, St. Louis, Missouri, USA

6. Department of Molecular Biology and Biotechnology, Universidade Federal do Rio Grande do Sul, Porto Alegre, Brazil

Abstract

The pathogenic yeast Cryptococcus neoformans presents a worldwide threat to human health, especially in the context of immunocompromise, and current antifungal therapy is hindered by cost, limited availability, and inadequate efficacy. After the infectious particle is inhaled, C. neoformans initiates a complex transcriptional program that integrates cellular responses and enables adaptation to the host lung environment.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Fundação de Amparo à Pesquisa do Estado do Rio Grande do Sul

Publisher

American Society for Microbiology

Subject

Virology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/mBio.03457-20

Reference118 articles.