Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility-Reference-Cited by-同舟云学术

Impact of Baloxavir Resistance-Associated Substitutions on Influenza Virus Growth and Drug Susceptibility

Published:2023-07-27 Issue:7 Volume:97 Page:
ISSN:0022-538X
Container-title:Journal of Virology
language:en
Short-container-title:J Virol

Author:

Hickerson Brady T.¹,Petrovskaya Svetlana N.²,Dickensheets Harold¹,Donnelly Raymond P.¹^ORCID,Ince William L.³,Ilyushina Natalia A.¹^ORCID

Affiliation:

1. Division of Biotechnology Review and Research II, Food and Drug Administration, Silver Spring, Maryland, USA

2. Division of Biotechnology Review and Research III, Food and Drug Administration, Silver Spring, Maryland, USA

3. Division of Antivirals, Food and Drug Administration, Silver Spring, Maryland, USA

Abstract

Baloxavir marboxil, an influenza virus polymerase acidic endonuclease inhibitor, represents a recently approved new class of influenza antivirals. Treatment-emergent resistance to baloxavir has been observed in clinical trials, and the potential spread of resistant variants could diminish baloxavir effectiveness.

Publisher

American Society for Microbiology

Subject

Virology,Insect Science,Immunology,Microbiology

Link

https://journals.asm.org/doi/pdf/10.1128/jvi.00154-23

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